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Search Results for " dopamine transporter "

44

抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T39429	AHN 1-055 hydrochloride 3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride	Dopamine Receptor	GPCR/G Protein; Neuroscience
	AHN 1-055 hydrochloride (3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride) 与多巴胺转运蛋白具有高亲和力，是多巴胺摄取抑制剂，IC50为 71 nM。
T22714	Decynium 22	Others	Others
	Decynium 22 是有机阳离子转运蛋白和单胺转运蛋白的抑制剂，具有抗抑郁作用。
T0322	Fipexide	Dopamine Receptor; AChR	GPCR/G Protein; Neuroscience
	Fipexide 是对氯苯乙酸衍生物，是哌嗪化学类的精神活性药物，作为促智药物，有用于老年痴呆的研究潜力。它可降低了纹状体腺苷酸环化酶的活性，通过多巴胺能神经传递对认知表现出积极的作用。
T11087	DOV-216,303 Free Base DOV-216303	Dopamine Receptor; Serotonin Transporter; Norepinephrine	GPCR/G Protein; Neuroscience
	DOV-216,303 Free Base (DOV-216303) 是血清素、去甲肾上腺素和多巴胺再摄取的抑制剂，IC50 为 14、20 和 78 nM。 DOV-216,303 Free Base 具有抗抑郁作用。
T1993	J-147 J147	Epigenetic Reader Domain; Dopamine Receptor; Monoamine Oxidase	Chromatin/Epigenetic; GPCR/G Protein; Neuroscience
	J-147 是一种高效的、具有口服活性的、可透过血脑屏障神经保护剂，可增强认知能力。它抑制单胺氧化酶 B 和多巴胺转运体，EC50分别为 1.88 μM 和 0.649 μM。它有研究阿尔茨海默氏症的潜力。
T6414	Bisacodyl 比沙可啶,Fenilaxan,Dulcolax,Brocalax	Others	Others
	Bisacodyl (Fenilaxan) 是刺激性缓泻剂，可直接作用于结肠以产生排便。它能够直接激活结肠巨噬细胞来增加 PGE2的分泌。PGE2充当旁分泌因子并减少结肠中 AQP3 的表达，抑制水从腔向血管一侧的转移，进而产生通便作用。
T3526	Dasotraline hydrochloride SEP-225289 hydrochloride,达索曲林盐酸盐	Dopamine Receptor; 5-HT Receptor; Serotonin Transporter; Norepinephrine	GPCR/G Protein; Neuroscience
	Dasotraline hydrochloride (SEP-225289 hydrochloride) 是具有阻断多巴胺 (IC50=4 nM)，去甲肾上腺素 (IC50=6 nM) 和三羟色胺转运蛋白 (IC50=11 nM)的三重再摄取抑制剂。
T10758L	Centanafadine hydrochloride EB-1020 hydrochloride	Dopamine Receptor; Serotonin Transporter; Adrenergic Receptor; Norepinephrine	GPCR/G Protein; Neuroscience
	Centanafadine hydrochloride (EB-1020 hydrochloride) 是一种去甲肾上腺素(NE)/多巴胺(DA)转运的双抑制剂，还能抑制5-羟色胺(serotonin)转运体。它对人 NE，DA 和5-羟色胺转运体的 IC50值分别为6 nM，38 nM 和 83 nM。
T0766	Promazine hydrochloride Romtiazin hydrochloride,Sinophenin hydrochloride,盐酸丙嗪	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; AChR	GPCR/G Protein; Neuroscience
	Promazine hydrochloride (Romtiazin hydrochloride) 是一种抗精神病药，也是一种多巴胺受体 (D2) 拮抗剂，能够抑制多巴胺能神经传递。
T1871	GBR 12935 dihydrochloride GBR12935,GBR-12935,GBR 12935	Dopamine Receptor	GPCR/G Protein; Neuroscience
	GBR 12935 dihydrochloride (GBR 12935) 是一种多巴胺再吸收抑制剂。
T2092	Amitifadine hydrochloride DOV-21947 hydrochloride,EB-1010 hydrochloride	Dopamine Receptor; 5-HT Receptor; Serotonin Transporter; Norepinephrine	GPCR/G Protein; Neuroscience
	Amitifadine hydrochloride (EB-1010 hydrochloride) 是一种 5-羟色胺-去甲肾上腺素-多巴胺的再摄取抑制剂(SNDRI)，其在 HEK 293 细胞中测得的 IC50值分别为 12， 23， 96 nM。
T1336	Benztropine mesylate Benzotropine mesylate,苯扎托品,Benzatropine mesylate,Benztropine methanesulfonate,甲磺酸苯扎托品	Dopamine Receptor; AChR; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Benztropine mesylate (Benztropine methanesulfonate) 是一种可口服的中枢性抗胆碱能剂，用于帕金森氏病的研究。它是抗组胺剂，抑制多巴胺的吸收。它也是人 D2多巴胺受体的变构拮抗剂，具有抗癌症干细胞的作用。
T0991	Desipramine hydrochloride NSC-114901,Desmethylimipramine,盐酸去甲咪嗪,JB-8181,EX-4355,Norimipramine,G-35020	Dopamine Receptor; 5-HT Receptor; Serotonin Transporter; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Desipramine hydrochloride (Norimipramine) 是一种二苯并氮杂类衍生物三环类抗抑郁药，可作为选择性去甲肾上腺素再摄取抑制剂。它还显示出较弱的 5-羟色胺再摄取抑制、α1 阻断、抗组胺和抗胆碱能作用。
T7745	Diclofensine hydrochloride 4-(3,4-二氯苯)-7-甲氧基-2-甲基-1,2,3,4-四氢异喹啉盐酸盐,Ro 8-4650 hydrochloride	Others; Dopamine Receptor	GPCR/G Protein; Neuroscience; Others
	Diclofensine hydrochloride (Ro 8-4650 hydrochloride) 是一种高效单胺再摄取抑制剂，在大鼠脑突触体中能够阻断多巴胺 (IC50=0.74 nM)、去甲肾上腺素 (IC50=2.3 nM) 和 5-羟色胺 (IC50=3.7 nM)。
T7153	Vanoxerine dihydrochloride GBR-12909 dihydrochloride,伐诺司林二盐酸盐,I893 dihydrochloride	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) 是一种竞争性的、有效的、选择性的多巴胺再摄取抑制剂，能够与多巴胺转运体 (DAT) 上的靶点结合。
T7341	Diclofensine Ro 8-4650,(+/-)-双氮奋兴	Dopamine Receptor; Monoamine Transporter	GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Diclofensine (Ro 8-4650) 是一种高效单胺再摄取抑制剂，在大鼠脑突触体中能够阻断多巴胺 (IC50=0.74 nM)、去甲肾上腺素 (IC50=2.3 nM) 和 5-羟色胺 (IC50=3.7 nM)。
T7734	BETA-CFT sulfate	Others	Others
	BETA-CFT sulfate 是BETA-CFT 的衍生物。BETA-CFT 是多巴胺转运蛋白（DATs）的拮抗剂。
T23234	Rimcazole dihydrochloride	Others	Others
	Rimcazole dihydrochloride 是 Rimcazole 的盐酸盐，是一种σ受体拮抗剂。Rimcazole dihydrochloride 还与多巴胺转运蛋白结合，抑制多巴胺的摄取。
T0948	Adrenalone hydrochloride Adrenalone HCl,肾上腺酮盐酸盐,盐酸肾上腺酮	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Adrenalone hydrochloride (Adrenalone HCl) 是一种多巴胺β氧化酶 (dopamine β oxidase) 抑制剂，结构与去甲肾上腺素转运蛋白 (NET) 配体相似，IC50=36.9 μM。它是一种肾上腺素能 (adrenergic) 激动剂，用作局部血管收缩剂和止血剂。
T41194	FFN 102 mesylate	Others	Others
	FFN 102 mesylate 是pH 响应型荧光假神经递质(FFN)，作为选择性多巴胺转运蛋白(DAT)和VMAT2底物。FFN 102 mesylate 与38个中枢神经系统受体(包括多巴胺和血清素受体)无明显结合。它的Ex-max在pH 值5时为340 nm，在pH 值7.5时为370 nm，在pH 值为5和7.5时，Em-max为435 nm。
T9169	MPP+ iodide	Mitochondrial Metabolism; Autophagy	Autophagy; Metabolism
	MPP+ iodide 是一种 5-羟色胺转运体的高亲和力底物，也是一种神经毒素 MPTP 的有毒代谢物，通过选择性破坏黑质多巴胺能神经元，在动物模型中引起帕金森病症状。它被多巴胺转运体吸收进入多巴胺能神经元，通过影响呼吸链复合体 I 对线粒体发挥神经毒性作用。
T22959	m-Chlorophenylbiguanide hydrochloride 1-(3-Chlorophenyl)biguanidehydrochloride,1-(3-氯苯基)双胍	5-HT Receptor	GPCR/G Protein; Neuroscience
	m-Chlorophenylbiguanide hydrochloride 是一种 5-HT3 受体激动剂。它选择性结合 5-HT3(Ki: 0.002 µM) 超过 5-HT1A(Ki: 10 µM) 和 5-HT2(Ki: 10 µM) 受体，但也结合多巴胺转运蛋白上的高亲和力和低亲和力位点( DAT；IC50：在大鼠尾状壳核突触体膜中分别为 0.4 和 34.8 µM）。
T0255	Clomipramine hydrochloride Clomipramine HCl,Anafranil,盐酸氯米帕明	Dopamine Receptor; 5-HT Receptor; Serotonin Transporter; Norepinephrine; GST	GPCR/G Protein; Neuroscience; oxidation-reduction
	Clomipramine hydrochloride (Anafranil) 是一种5-羟色胺转运体(Ki:0.14 nM)、去甲肾上腺素转运体(Ki:54 nM)和多巴胺转运体(Ki:3 nM)阻断剂。
T0869	Atomoxetine hydrochloride Tomoxetine hydrochloride,(R)-Tomoxetine hydrochloride,盐酸托莫西汀,LY 139603,Atomoxetine HCl,LY 139603 HCl	Dopamine Receptor; 5-HT Receptor; Norepinephrine	GPCR/G Protein; Neuroscience
	Atomoxetine hydrochloride (LY 139603) 是苯氧基-3-丙胺衍生物和选择性非兴奋剂，是去甲肾上腺素再摄取抑制剂，具有认知增强活性。与人 NET，SERT 和 DAT 的放射性配体结合的 Ki 分别为5，77和1451 nM。
T23501	Vanoxerine	Others	Others
	Vanoxerine is an antagonist of dopamine transporter (Ki: 16.9nM).
T29920	Altropane
	Altropane is a SPECT imaging agent used for viewing dopamine transporter sites.
T10758	Centanafadine EB-1020	Others	Others
	Centanafadine is a dual inhibitor of norepinephrine (NE)/dopamine (DA) transporter, also inhibits serotonin transporter (IC50s: 6 nM, 38 nM, and 83 nM for human NE, DA, and serotonin transporter).
T24712	Rimcazole
	Rimcazole is a sigma receptor antagonist. It also binds to the dopamine transporter and inhibiting dopamine uptake.
T26145	RTI 336 RTI336,RTI-336
	RTI 336 is used as a chronic brain dopamine transporter (DAT) inhibitor.
T27036	CL-216303 HCl DOV-216303,DOV216303,CL 216303,CL-216303,DOV 216303,CL216303
	CL-216303 HCl, a dopamine transporter inhibitor and a 5-HT inhibitor, is used potentially for the treatment of depression.
T36949	Niaprazine	5-HT Receptor; Adrenergic Receptor; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Niaprazine 是有效的组胺 H1 受体拮抗剂，具有抗组胺和抗血清素活性。Niaprazine 在睡眠障碍方面有研究的价值。
T10842	Clomipramine D3 氯米帕明 D3	Others	Others
	Clomipramine D3 is the deuterium-labeled Clomipramine. Clomipramine is a serotonin transporter, norepinephrine transporter dopamine transporter blocker (Ki: 0.14, 54 and 3 nM).
T10842L	Clomipramine D3 hydrochloride	Others	Others
	Clomipramine D3 hydrochloride is the deuterium-labeled Clomipramine. Clomipramine is a serotonin transporter, norepinephrine transporter dopamine transporter blocker (Ki: 0.14, 54 and 3 nM).
T24956	(18F)LBT 999 (18F)LBT999,LBT999 18F,LBT 999 18F,LBT-999 18F,(18F)LBT-999
	(18F)LBT 999 is a positron emission tomography (PET) tracer, used for the quantification of the dopamine transporter (DAT) in the healthy rat brain.
T31758	Fecnt F-18 J2.661.350G,18F-Fecnt,(18F)-Fecnt
	[F-18] FECNT has been widely used to calculate dopamine transporter (DAT) occupancy rates in the brains of non-human primates and can distinguish DAT density differences between Parkinson's disease and healthy human controls.
T37699	Org 24598
	Potent and selective inhibitor of the glial glycine transporter GlyT1b (IC50 = 6.9 nM). Displays negligible activity at GlyT-2, adrenoreceptors, dopamine, 5HT receptors and noradrenaline, dopamine, 5HT and GABA transporters (pIC50 in vivo. Chue et al (2013) Glycine reuptake inhibition as a new therapeutic approach in schizophrenia: focus on the glycine transporter 1 (GlyT1). Curr.Pharm.Des. 19 1311 PMID:23194655 \|Brown et al (2001) Discovery and SAR of org 24598-a selective glycine uptake inhibi...
T27689	JNJ-7925476 HCl JNJ-7925476,JNJ7925476,JNJ 7925476
	JNJ-7925476 HCl is a triple monoamine uptake inhibitor. JNJ-7925476 Salt blocks the dopamine transporter (DAT), norepinephrine transporter (NET) and serotonin transporter (SERT) in the central nervous system. The ED(50) values for JNJ-7925476 occupancy of
T70615	TAS-303
	TAS-303 is a selective norepinephrine reuptake inhibitor which displays significant norepinephrine transporter (NET) inhibitory activity toward serotonin or dopamine transporters. Radioligand-binding studies showed that TAS-303 selectively and potently inhibited [3H]norepinephrine binding to the human NET.
T79264	Z1078601926
	Z1078601926为hDAT (人多巴胺转运蛋白) 的变构抑制剂，且与诺米芬辛表现出协同效应。
T71772	Bicifadine free base
	Bicifadine, also known as DOV-220075, CL 220,075, is a SNDR inhibitor potentially for the treatment of lower back pain. Bicifadine has a non-opioid, non-NSAID mechanism for the treatment of pain, which should have less abuse potential than opioid drugs and less propensity to cause gastric ulcers than NSAID drugs. While the drug is purported to be a serotonin (SERT) and noradrenaline transporter (NET) inhibitor, it also has effects at the dopamine transporter (DAT), effectively making it a broad...
T70914	GBR-12935 maleate
	GBR-12935 is a potent and selective dopamine reuptake inhibitor. It was originally developed in its 3H radiolabelled form for the purpose of mapping the distribution of dopaminergic neurons in the brain by selective labelling of dopamine transporter proteins. This has led to potential clinical uses in the diagnosis of Parkinson's disease, although selective radioligands such as Ioflupane (Â¹Â²Â³I) are now available for this application. GBR-12935 is now widely used in animal research into Parkin...
T70960	Maprotiline-d3 hydrochloride
	Maprotiline-d3 is intended for use as an internal standard for the quantification of maprotiline by GC- or LC-MS. Maprotiline is a tricyclic antidepressant. It binds to the norepinephrine transporter (NET) and is selective for NET over the serotonin and dopamine transporters. Maprotiline also binds to the serotonin (5-HT) receptor subtype 5-HT2A, as well as histamine H1, muscarinic acetylcholine, α1-adrenergic, and dopamine D2 receptors. In vivo, maprotiline inhibits norepinephrine reuptake in r...
T83888	(S)-5-hydroxy-6-methoxy Duloxetine maleate
	(S)-5-羟基-6-甲氧基Duloxetine是(S)-duloxetine的一个活性代谢物，主要通过对血清素(5-HT)和去甲肾上腺素的再摄取进行抑制。它通过(S)-duloxetine经过一个5-或6-羟基Duloxetine中间体以及一个儿茶酚Duloxetine中间体形成，这些中间体由细胞色素P450 (CYP)同型酶CYP1A2和CYP2D6形成。(S)-5-羟基-6-甲氧基Duloxetine在脂质膜中抑制5-HT转运体(SERT)、去甲肾上腺素转运体(NET)和多巴胺转运体(DAT)，其对人类转运体的抑制常数(Kis)分别为266、920和2,814 nM。
T37800	PF-04449613
	PF-04449613 is a phosphodiesterase 9A (PDE9A) inhibitor (IC50= 22 nM).1It is selective for PDE9A over PDE1C (IC50= >1,000 nM), as well as over a variety of other PDEs, inhibiting PDE2-8, -10, and -11 activity by less than 30% in a panel of enzymes, ion channels, and transporters at 1 μM but does inhibit the human dopamine transporter (DAT; Ki= 293 nM). PF-04449613 (0.1-100 mg/kg, s.c.) increases cerebrospinal fluid (CSF) levels of cyclic GMP (cGMP) in rats. Subcutaneous administration of PF-0444...

化合物

AHN 1-055 hydrochloride

Cat.No: T39429

Synonym: 3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride

Target: Dopamine Receptor

Cat.No: T22714

Target: Others

Cat.No: T0322

Target: Dopamine Receptor, AChR

DOV-216,303 Free Base

Cat.No: T11087

Synonym: DOV-216303

Target: Dopamine Receptor, Serotonin Transporter, Norepinephrine

Cat.No: T1993

Synonym: J147

Target: Epigenetic Reader Domain, Dopamine Receptor, Monoamine Oxidase

Cat.No: T6414

Synonym: 比沙可啶,Fenilaxan,Dulcolax,Brocalax

Target: Others

Dasotraline hydrochloride

Cat.No: T3526

Synonym: SEP-225289 hydrochloride,达索曲林盐酸盐

Target: Dopamine Receptor, 5-HT Receptor, Serotonin Transporter, Norepinephrine

Centanafadine hydrochloride

Cat.No: T10758L

Synonym: EB-1020 hydrochloride

Target: Dopamine Receptor, Serotonin Transporter, Adrenergic Receptor, Norepinephrine

Promazine hydrochloride

Cat.No: T0766

Synonym: Romtiazin hydrochloride,Sinophenin hydrochloride,盐酸丙嗪

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, AChR

GBR 12935 dihydrochloride

Cat.No: T1871

Synonym: GBR12935,GBR-12935,GBR 12935

Target: Dopamine Receptor

Amitifadine hydrochloride

Cat.No: T2092

Synonym: DOV-21947 hydrochloride,EB-1010 hydrochloride

Target: Dopamine Receptor, 5-HT Receptor, Serotonin Transporter, Norepinephrine

Benztropine mesylate

Cat.No: T1336

Synonym: Benzotropine mesylate,苯扎托品,Benzatropine mesylate,Benztropine methanesulfonate,甲磺酸苯扎托品

Target: Dopamine Receptor, AChR, Histamine Receptor

Desipramine hydrochloride

Cat.No: T0991

Synonym: NSC-114901,Desmethylimipramine,盐酸去甲咪嗪,JB-8181,EX-4355,Norimipramine,G-35020

Target: Dopamine Receptor, 5-HT Receptor, Serotonin Transporter, Adrenergic Receptor

Diclofensine hydrochloride

Cat.No: T7745

Synonym: 4-(3,4-二氯苯)-7-甲氧基-2-甲基-1,2,3,4-四氢异喹啉盐酸盐,Ro 8-4650 hydrochloride

Target: Others, Dopamine Receptor

Vanoxerine dihydrochloride

Cat.No: T7153

Synonym: GBR-12909 dihydrochloride,伐诺司林二盐酸盐,I893 dihydrochloride

Target: Dopamine Receptor

Cat.No: T7341

Synonym: Ro 8-4650,(+/-)-双氮奋兴

Target: Dopamine Receptor, Monoamine Transporter

BETA-CFT sulfate

Cat.No: T7734

Target: Others

Rimcazole dihydrochloride

Cat.No: T23234

Target: Others

Adrenalone hydrochloride

Cat.No: T0948

Synonym: Adrenalone HCl,肾上腺酮盐酸盐,盐酸肾上腺酮

Target: Adrenergic Receptor

FFN 102 mesylate

Cat.No: T41194

Target: Others

Cat.No: T9169

Target: Mitochondrial Metabolism, Autophagy

m-Chlorophenylbiguanide hydrochloride

Cat.No: T22959

Synonym: 1-(3-Chlorophenyl)biguanidehydrochloride,1-(3-氯苯基)双胍

Target: 5-HT Receptor

Clomipramine hydrochloride

Cat.No: T0255

Synonym: Clomipramine HCl,Anafranil,盐酸氯米帕明

Target: Dopamine Receptor, 5-HT Receptor, Serotonin Transporter, Norepinephrine, GST

Atomoxetine hydrochloride

Cat.No: T0869

Synonym: Tomoxetine hydrochloride,(R)-Tomoxetine hydrochloride,盐酸托莫西汀,LY 139603,Atomoxetine HCl,LY 139603 HCl

Target: Dopamine Receptor, 5-HT Receptor, Norepinephrine

Cat.No: T23501

Target: Others

Cat.No: T29920

Cat.No: T10758

Synonym: EB-1020

Target: Others

Cat.No: T24712

Cat.No: T26145

Synonym: RTI336,RTI-336

Cat.No: T27036

Synonym: DOV-216303,DOV216303,CL 216303,CL-216303,DOV 216303,CL216303

Cat.No: T36949

Target: 5-HT Receptor, Adrenergic Receptor, Histamine Receptor

Clomipramine D3

Cat.No: T10842

Synonym: 氯米帕明 D3

Target: Others

Clomipramine D3 hydrochloride

Cat.No: T10842L

Target: Others

Cat.No: T24956

Synonym: (18F)LBT999,LBT999 18F,LBT 999 18F,LBT-999 18F,(18F)LBT-999

Cat.No: T31758

Synonym: J2.661.350G,18F-Fecnt,(18F)-Fecnt

Cat.No: T37699

JNJ-7925476 HCl

Cat.No: T27689

Synonym: JNJ-7925476,JNJ7925476,JNJ 7925476

Cat.No: T70615

Cat.No: T79264

Bicifadine free base

Cat.No: T71772

GBR-12935 maleate

Cat.No: T70914

Maprotiline-d3 hydrochloride

Cat.No: T70960

(S)-5-hydroxy-6-methoxy Duloxetine maleate

Cat.No: T83888

Cat.No: T37800

Cat. No.	Product Name	Target	Signaling Pathways
TN6552	5,7-Dimethoxyluteolin	Dopamine Receptor	GPCR/G Protein; Neuroscience
	5,7-Dimethoxyluteolin 是 5,7-二甲基木犀草素的一种衍生物，可以活化多巴胺转运蛋白，EC50为 3.417 μM。

天然产物

5,7-Dimethoxyluteolin

Cat.No: TN6552

Target: Dopamine Receptor

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